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Drug Delivery Systems for Metabolic Disorders presents the most
recent developments on the targeted delivery of drugs to deal with
metabolic disorders in a safe, compliant and continuous way. The
book covers recent developments in advanced drug delivery systems
in various metabolic disorders, including disturbances in protein,
lipid, carbohydrate and hormone metabolism and lysosomal and
mitochondrial disorders. It provides a brief introduction to
metabolic disorders, along with a focus on the current landscape
and trends in understanding disease pathology using different in
vitro and in vivo models required for clinical applications and
developments of new therapeutics. Each subsequent chapter covers
drug delivery systems dedicated to metabolic diseases caused by
disturbances in protein, lipid, carbohydrate and hormone
metabolism. Then, it moves on to cover lysosomal storage disorders
and applications of phytopharmaceuticals in this context. This is
the perfect reference for researchers in pharmaceutical science who
are interested in developing new treatments for metabolic diseases.
COVID Transmission Modeling: An Insight into Infectious Diseases
Mechanism provides an interdisciplinary overview of the COVID-19
pandemic crisis and covers various aspects of newer modeling
techniques and practical solutions for health emergencies. This
book aims to formulate various innovative and pragmatic
mathematical, statistical, and epidemiological models using
COVID-19 real data sets. It emphasizes interdisciplinary
theoretical postulates derived from practical insights and
knowledge of public health. Each of the book's 12 chapters provides
invaluable and exploratory tools to enable explicit assumptions,
highlights key health indicators, and determines the geometric
progression and control measures of the disease. The present
developed models will allow readers to extrapolate the exact reason
for the outbreak and pave the way for scientific information on
vaccine trials and socioeconomic, psychological, and disease burden
worldwide. These advanced techniques of modeling and their
applications are in greater need than ever for effective connection
between mathematicians, statisticians, epidemiologists,
researchers, clinicians, and policymakers for making appropriate
decisions at the right time. With the advent of emerging health
science, all models are demonstrated with real-life data sets and
provided with illustrations and eye-catching graphs and diagrams so
that the readers can easily understand the concept of COVID-19
pandemic interventions and their control measures, and their
impact. Features Addresses all aspects of mitigation/control
measures, estimation of transmission rate, economic impact
assessment, genetic complexity of COVID-19, herd immunity, and
various methods, including newer mathematical, statistical, and
epidemiological models in the analysis of COVID-19 pandemic
outbreak Covers the application of innovative, advanced statistical
and epidemiological models and demonstrates possible solutions
toward supportive treatment aspects of COVID-19 and its control
measures Includes models that can easily be followed in formulating
the mathematical derivations and key points Supplemented with ample
illustrations, images, diagrams, and figures This book is aimed at
postgraduate students studying medicine and healthcare,
mathematics, and statistical information. Researchers will also
find this book very helpful.
Discussing existing techniques, ongoing research, new approaches,
and basic concepts in the treatment of nail diseases, Topical Nail
Products and Ungual Drug Delivery summarizes the current knowledge
and represents a jumping-off point for creating novel techniques of
drug delivery across the nail. A growing area of pharmaceutical
research, the search for efficient delivery techniques that can
cross the nail barrier has yielded several effective strategies,
brought together in this book. Topics Include Nail anatomy,
physiology, diseases, and treatment Permeability of the nail plate
Topical nail formulations Approaches to enhance ungual and
trans-ungual drug delivery In vitro and in vivo models to evaluate
topical nail formulations Nail sampling techniques Bioengineering
of the nail Trans-ungual iontophoresis Pharmacokinetics of drugs in
the nail apparatus Onychopharmacokinetics: proposed model insight
Photodynamic therapy of nail diseases The nail as a surrogate for
investigating drug use
Novel drug delivery technologies strive to bypass challenging
biological layers to elicit desired pharmacological activity. The
skin, one of our key defensive barriers, allows certain topically
applied substances and toxins to pass. The dermatokinetics of a
drug determines the efficacy of treatment of skin disorders.
Presenting the first comprehensive reference on this important area
of research, Dermatokinetics of Therapeutic Agents includes a
general overview of the theoretical as well as practical aspects of
dermatokinetics and addresses the impact of a drug delivery system
on the dermatokinetics of drugs. Chapters and illustrations cover
introductory aspects and the significance, methods, and models used
in dermatokinetic studies of therapeutic agents. Topics include:
Theoretical Models for Dermatokinetics of Therapeutic Agents Drug
Delivery Approaches to Modulate Dermatokinetics of Drugs
Conventional Methods of Cutaneous Drug Sampling Cutaneous
Microdialysis Sampling Substrates by Skin Permeabilization
Spectroscopic Techniques in Dermatokinetics Studies Regulatory
Perspective of Dermatokinetic Studies
Discussing existing techniques, ongoing research, new approaches,
and basic concepts in the treatment of nail diseases, Topical Nail
Products and Ungual Drug Delivery summarizes the current knowledge
and represents a jumping-off point for creating novel techniques of
drug delivery across the nail. A growing area of pharmaceutical
research, the search for efficient delivery techniques that can
cross the nail barrier has yielded several effective strategies,
brought together in this book. Topics Include Nail anatomy,
physiology, diseases, and treatment Permeability of the nail plate
Topical nail formulations Approaches to enhance ungual and
trans-ungual drug delivery In vitro and in vivo models to evaluate
topical nail formulations Nail sampling techniques Bioengineering
of the nail Trans-ungual iontophoresis Pharmacokinetics of drugs in
the nail apparatus Onychopharmacokinetics: proposed model insight
Photodynamic therapy of nail diseases The nail as a surrogate for
investigating drug use
This book presents models describing HIV transmission rates at
population level, discussing the main statistical methods and
analytical interventions. It also assesses the practical
applicability of the various modelling techniques, offering readers
insights into what methods are available and, more importantly,
when they should be used to address HIV transmission at global
level. The book includes realistic simulation models fitted to
clarify the rate of HIV mother-to-child transmission (HIV MTCT),
and substantiates the conclusions that can be drawn as well as the
appropriate time for making global-level clinical decisions
concerning people living with HIV/AIDS (PLHIVs). Intended for
students, academics and researchers, the book offers more than just
an introduction to the topic - it also features in-depth, yet
easy-to-understand, descriptions of a new mathematical/statistical
HIV mother-to-child transmission model, making it a useful resource
for clinicians, public health workers and policymakers involved in
implementing HIV-prevention programmes at national /global level.
This book presents models describing HIV transmission rates at
population level, discussing the main statistical methods and
analytical interventions. It also assesses the practical
applicability of the various modelling techniques, offering readers
insights into what methods are available and, more importantly,
when they should be used to address HIV transmission at global
level. The book includes realistic simulation models fitted to
clarify the rate of HIV mother-to-child transmission (HIV MTCT),
and substantiates the conclusions that can be drawn as well as the
appropriate time for making global-level clinical decisions
concerning people living with HIV/AIDS (PLHIVs). Intended for
students, academics and researchers, the book offers more than just
an introduction to the topic - it also features in-depth, yet
easy-to-understand, descriptions of a new mathematical/statistical
HIV mother-to-child transmission model, making it a useful resource
for clinicians, public health workers and policymakers involved in
implementing HIV-prevention programmes at national /global level.
Transportation Engineering Basics, Second Edition shows students
how to use classroom knowledge to solve real-life transportation
and traffic engineering problems. This comprehensive labbook
addresses congestion, air pollution, transit, financing, politics,
and signals. Each user-friendly chapter is designed as lab work,
providing essential theory, background information, figures,
tables, worksheets, and questions. Each lab is uniformly structured
so that the engineering student can easily see and understand the
lab's objective and the components necessary to investigate the
situation. This updated and expanded edition includes ten new labs
and incorporates changes resulting from the Intermodal Surface
Transportation Efficiency Act (ISTEA, 1990) and the Transportation
Equity Act of the 21st Century (TEA-21, 1998). This legislation has
provided opportunities for transportation professionals in terms of
new funds and jobs; as well as set new requirements for monitoring
performance and showing the benefits of a project. ""Transportation
Engineering Basics, Second Edition"" includes information about job
opportunities, a section on software use, summaries of
transportation websites, a list of esteemed transportation
journals, and a glossary of terms used in the transportation field.
Teachers will find the book valuable in assigning students
practical work, conducting research and solving transportation
related problems by collecting data from the field, and gaining
practical knowledge. Planners and experienced professionals will
also find the book to be a valuable resource and beneficial in
assisting them with their work.
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Ruggine fogliare del caffè
K Soumya, Konnapa Narasimha Murthy, A C Udayashankar
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R1,031
Discovery Miles 10 310
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Ships in 10 - 15 working days
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Novel drug delivery technologies strive to bypass challenging
biological layers to elicit desired pharmacological activity. The
skin, one of our key defensive barriers, is imperfect, and may
allow certain topically applied substances or toxins to pass. The
dermatokinetics of a drug determines the efficacy of treatment of
skin disorders. Presenting the first comprehensive reference on
this important area of research, Dermatokinetics of Therapeutic
Agents includes a general overview of the theoretical as well as
practical aspects of dermatokinetics and addresses the impact of
nature of a drug delivery system on the dermatokinetics of drugs.
Chapters and illustrations cover the introductory aspects
significance, methods, and models used in dermatokinetic studies of
therapeutic agents. Topics include: * Theoretical Models for
Dermatokinetics of Therapeutic Agents * Drug Delivery Approaches to
Modulate Dermatokinetics of Drugs * Conventional Methods of
Cutaneous Drug Sampling * Cutaneous Microdialysis * Sampling
Substrates by Skin Permeabilization * Spectroscopic Techniques in
Dermatokinetics Studies * Regulatory Perspective of Dermatokinetic
Studies
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Discovery Miles 3 300
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